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Intraoperative Microscope-integrated Optical Coherence Tomography for Subretinal Gene Therapy Delivery

Intraoperative Microscope-integrated Optical Coherence Tomography for Subretinal Gene Therapy Delivery ABSTRACT Purpose: To report the novel use of microscope-integrated optical coherence tomography (MIOCT) as an adjunct to delivery of subretinal gene therapy. Setting: The Bascom Palmer Eye Institute, Miami, FL, USA Methods: The MIOCT was used intraoperatively during subretinal injections of adeno-associated viral serotype 2 vector (AAV2)...

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Stem Cell Therapy for Retinal Disorders: Generation of Human RPE from Skin Biopsies of AMD Patients

Stem Cell Therapy for Retinal Disorders: Generation of Human RPE from Skin Biopsies of AMD Patients ABSTRACT Purpose: Retinal pigmented epithelium (RPE) derived from human induced pluripotent stem (iPS) cells is a promising source of cells for the replacement of degenerated RPE in patients with age-related macular degeneration (AMD), as use of patient-specific iPS will avoid the issue of graft rejection. Here we demonstrate that iPS can...

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Long-term Outcomes of Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cell Transplantation for Retinal Degeneration from Two Phase I/II Trials

Long-term Outcomes of Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cell Transplantation for Retinal Degeneration from Two Phase I/II Trials ABSTRACT Purpose: To summarize long-term safety data and clinical outcomes of two prospective phase I/II studies assessing safety and tolerability of human Embryonic Stem Cell (hESC) derived retinal pigment epithelial (MA09-hRPE) cell transplantation in patients with atrophic...

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Difficulties of Surgical Procedure During Experimental Transplantation of Retinal Pigmented Epithelial Cells in a Large Animal Model

Difficulties of Surgical Procedure During Experimental Transplantation of Retinal Pigmented Epithelial Cells in a Large Animal Model ABSTRACT Purpose: To report surgical difficulties during experimental transplantation of retinal pigmented epithelial cells in subretinal space on eyes of large animal model using nanofibers scaffold and injector. Methods: Six eyes of minipigs underwent standard 3-port 23 G PPV. Implantation of nanofibers...

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An Introduction to RPE Transplantation

An Introduction to RPE Transplantation ABSTRACT CONTACT DETAILS   Ron Adelman New Haven, CT, USA Email:...

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Argus II Epiretinal Prosthesis System Implantation in End-stage Retinitis Pigmentosa – Results of the First Four Patients

Argus II Epiretinal Prosthesis System Implantation in End-stage Retinitis Pigmentosa – Results of the First Four Patients ABSTRACT Purpose: Argus II Epiretinal prosthesis system implantation is indicated in patients older tha 25-yers of age with end-stage retinitis pigmentosa with bilateral vision of hand motion, or light perception only. In this study our purpose was to evaluate the efficacy and safety of Argus II Retinal...

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