The study was conducted on six fresh porcine eyeballs (1 day after slaughter). The eyeballs were prepared by the removal of the cornea, iris and lens, without damaging the anterior hyaloid membrane of the vitreous. To prevent vitreous prolapse and eyeball distortion during Ozurdex injection, a sclerotomy was performed in all the eyes prior to surgical manipulations. The sclerotomy site was marked with gentian. The experiment was conducted using the I-Speed camera (Olympus), with a recording rate up to 150,000 frames per second (fps). When applying xenon lamp with panoramic fiber optic 20G (BrightStar, DORC) and top axial LED illumination we were able to obtain a recording rate of 2,000 fps. As far as we are concerned, this has been the most precise study of Ozurdex movements within the eye in the world. Our study showed that the implant did not move freely within the vitreous chamber, regardless of whether it contained the vitreous humor or BSS. Mean implant speed in the vitreous was 4.1 m/s and it covered the distance of 10.937 mm, while in the BSS the mean speed was 0.841 m/s and the distance was 9.21 mm. It is worth emphasizing that the implant speed decreased rapidly, both in the vitreous and in the BSS, when it left the applicator. Speed reduction was from 4.28 m/s to 3.2 m/s in the vitreous, and from 1.15 m/s to 0.56 m/s in the BSS. The time of the vitreous vibration following the implant injection was also measured, and the vitreous was completely calm after about 25-30 seconds. Such a long time of the vitreous shaking may in some cases lead to retinal tear or macular hole formation.

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