Barbara Delas, Cláudia Antunes*, Lorena Almudi, Mouafk Asaad (Terrassa, Spain)


To report good clinical outcome in a patient with bilateral choroidal neovascularization (CNV) associated to optic nerve head drusen (ONHD), treated with intravitreal ranibizumab injection.


A 12-year-old girl was referred for loss of right eye vision detected in a routine checkup. Best corrected visual acuity (BCVA) was hand movements in the right eye and 0.9 in the left eye. Funduscopy revealed the presence of superficial and buried bilateral ONHD, confirmed by ultrasonography and computed tomography, and the study was completed with perimetry. The presence of bilateral CNV, active in the right eye, was observed and subsequently confirmed using fluorescein angiography and optical coherence tomography.


Treatment with two consecutive injections of intravitreal ranibizumab resulted in inactivation of the neovascular membrane with subretinal fluid reabsorption and improved right eye BCVA; after 12 months follow up, this was 0.3 and stable.


Although there are no published studies of safety in children, antiangiogenic therapy for CNV secondary to OND may be useful and safe. A search of the literature came up with just one previously reported cases of OND-associated CNV treated with antivascular endothelial growth factor alone.