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Fractal Dimensional Analysis of Optical Coherence Tomography Angiography in Chronic Diabetic Macular

ABSTRACT Purpose: To determine the effect of sustained-release fluocinolone acetonide (0,2 µg/day FAc) intravitreal implant in the superficial capillary complex, imaged by optical coherence tomography angiography (OCTA) in patients with diabetic macular edema (DME), using the fractal dimension analysis. Methods: A prospective analysis was performed in one eye with a chronic refractory DME treated with FAc intravitreal implant. OCTA...

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Intravitreal Ocriplasmin in DME with Vitreomacular Adhesion in Eyes with Proliferative Diabetic Retinopathy

Intravitreal Ocriplasmin in DME with Vitreomacular Adhesion in Eyes with Proliferative Diabetic Retinopathy ABSTRACT Purpose: To evaluate the efficacy of a single intravitreal injection of ocriplasmin (125 µg) in eyes with diabetic macular edema (DME) and focal or loose broad vitreomacular adhesion/traction (VMA) in cases where proliferative diabetic retinopathy (PDR) was present and to compare these results with those obtained in...

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Safety and Efficacy of Intravitreal Ocriplasmin in DME with Vitreomacular Adhesion

Introduction: There are many reports supporting that the relationship of the posterior cortical vitreous to the macula plays a role in the development of diabetic macular edema (DME). Until recently, the only treatment option available for vitreomacular adhesion (VMA) was vitrectomy. Given the risks for vitrectomy, the standard of care has generally been to wait until visual symptoms from VMT have deteriorated enough to justify the...

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Ocular Manifestations of Familial Amyloidosis Transthyretin V30M Related: Impact of Liver Transplantation

SCIENTIFIC POSTER_Ines Casal_2 Familial amyloidosis TTR V30M is caused by an amino acid substitution of methionine for valine at position 30 of transthyretin (TTR), a transport protein. This leads to an extracellular amyloid deposition in peripheral nerves causing motory, sensory and autonomic neuropathy in solid organs and the eye. The major production of circulating TTR is in the liver, but some production occurs also in the choroid and...

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Familial Amyloidosis TTR V30M: What Happens in the Posterior Segment of the Eye?

SCIENTIFIC POSTER_Ines Casal_1 Familial amyloid polyneuropathy (FAP) is a group of autosomal dominant inherited diseases whose most frequent causative mutation is TTR V30M (a substitution of methionine for valine at position 30 in transthyretin). Transthyretin (TTR) is a normal serum protein which is mainly synthesized in the liver, but also in other tissues such as the choroid plexus and the retinal pigmented epithelium. This disorder is...

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Use of Ranibizumab for Neovascular Glaucoma in a Patient with Familial Amyloidosis Transthyretin V30M Related

SCIENTIFIC POSTER_Ines Casal_3 Introduction: Familial amyloidosis TTR V30M is an autosomal dominant inherited disorder caused by extracellular amyloid deposition in nerves, solid organs and in the eye. Several ocular manifestations were reported such as abnormal conjunctival vessels, keratoconjunctivitis sicca, amyloid deposits at the pupillary margin, glaucoma, deposition of amyloid at the anterior capsula of the lens, vitreous opacities...

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