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Suspension Phase Microsphere Immunoassay of Bevacizumab Levels in Ocular Fluids and Sera

Susan J. Wong, PhD (Albany, NY), Paul M. Beer, MD (Albany, NY) PURPOSE: Bevacizumab, a humanized monoclonal antibody targeting VEGF, is currently injected into vitreous humor to treat age-related macular degeneration. proliferative diabetic retinopathy and other conditions associatd with vascular leakage and angiogenesis. We developed a suspension phase microsphere immunoassay of free bevacizumab levels in ocular fluids and serum to enable...

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Vitreous Levels of Unbound Bevacizumab and Unbound Vascular Endothelial Growth Factors in Two Human Subjects

http://www.evrs.eu/medias/2006/congress/Vitreous-Levels-of-Unbound-Bevacizumab-and-Unbound-Vascular-Endothelial-Growth-Factors-in-Two-Human-Subjects.swf Paul M. Beer, MD (Albany, NY), Susan Wong, PhD (Albany, NY), Naomi S. Falk, MD (Albany, NY), Amjad Hammad, MD (Albany, NY), Samira Khan, (Albany, NY), MartinO’Malley, MD (Albany, NY) PURPOSE: Determination of vitreous levels of unbound VEGF and unbound bevacizumab in two patients who...

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