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Neurobiological Principles Applied to Retinal Diseases

Retinal and macular diseases are a major cause of visual impairment and affect the quality of life for millions worldwide. Clinical manifestations of retinal diseases result from perturbations in normal cellular behavior and adaptive changes to genetic mutations interacting with environmental factors. During the last years retinal surgery has fine-tuned the techniques and instrumentation, greatly increasing surgical success but not always...

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Subretinal Schwann Cell Injections Preserve Plexiform Synapses and Retinal Function in RCS Rats

Isabel Pinilla, MD (Zaragoza, Spain), Nicolás Cuenca, PhD (Alicante, Spain), Yves Sauvé, PhD (Edmonton, Canada), Gema Martínez-Navarrete, (Alicante, Spain), Emilio Abecia Martinez, MD (Zaragoza, Spain), Raymond D. Lund, PhD (Salt Lake City, UT) PURPOSE: To examine the preventive potential of subretinal injections of neurotrophin producing cells (Schwann cells) on retinal circuitry in the RCS (Royal College of Surgeons) rat model of...

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Preservation of Retinal Anatomy and Synaptic Connectivity Following Preventive Subretinal Injections of Human RPE Cells in the Royal College of Surgeons (RCS) Rat

I. Pinilla, Y. Sauvé, N. Cuenca, E. Abecia, R. D. Lund Purpose: To examine the effect of preventive subretinal cell injections in the RCS rat on the outer retina and synaptic connectivity between photoreceptors and their target neurons. Methods: Eight rats received subretinal injections of a human RPE cell line (ARPE19) at age P22; they were sacrificed at P90 (n=4) and P120 (n=4). Controls consisted of 6 unoperated rats sacrificed at the...

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