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Stem Cell Therapy for Retinal Disorders: Generation of Human RPE from Skin Biopsies of AMD Patients

Stem Cell Therapy for Retinal Disorders: Generation of Human RPE from Skin Biopsies of AMD Patients ABSTRACT Purpose: Retinal pigmented epithelium (RPE) derived from human induced pluripotent stem (iPS) cells is a promising source of cells for the replacement of degenerated RPE in patients with age-related macular degeneration (AMD), as use of patient-specific iPS will avoid the issue of graft rejection. Here we demonstrate that iPS can...

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Use of Double Reciprocal Analysis to Compare Pharmacological Treatments for Subfoveal Exudative AMD

Lucian V. Del Priore, MD, PhD (New York, NY), Ankoor R. Shah, BS (New York, NY) PURPOSE: Multiple pharmacological treatments (photodynamic therapy [PDT], Macugen, Lucentis, and Anecortave Acetate [AA]) exist for exudative AMD; typically these treatments are compared to controls in clinical trials but not to one another. We have shown the rate of visual loss in untreated eyes is linear on a double reciprocal Lineweaver-Burke (LB) plot with...

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Effect of Initial Visual Acuity on Visual Loss in Untreated AMD Eyes with Subfoveal Neovascularization

http://www.evrs.eu/medias/2006/congress/Effect-of-Initial-Visual-Acuity-on-Visual-Loss-in-Untreated-AMD-Eyes-with-Subfoveal-Neovascularization.swf Lucian V. Del Priore, MD, PhD (New York, NY), Ankoor R. Shah, BS (New York, NY) PURPOSE: Previous clinical trials in exudative AMD demonstrate large differences in the behavior of untreated control eyes. Herein we test the hypothesis that the behavior of the control eyes is essentially the same...

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