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The Effect of Intravitreal Anti-VEGF Agents on Peripheral Wound Healing in a Rabbit Mode

JB Christoforidis, R Ricketts, C Pratt, J Wang, A Jiang, H Herce, K LaPerle (Columbus, OH, USA) Advantages: To investigate the effect of intravitreal pegaptanib, bevacizumab and ranibizumab on blood vessel formation during cutaneous wound healing in a rabbit model and to compare this effect to placebo controls. Methods: Forty New Zealand white rabbits underwent full thickness cutaneous wounds using standard 6mm dermatologic punch biopsies....

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PET/CT Imaging of I-124 Radiolabeled Bevacizumab and Ranibizumab After Intravitreal Injection in a Rabbit Model

JB Christoforidis, MM Carlton, MV Knopp, GH Hinkle (Columbus, OH, USA) Advantages: To determine whether bevacizumab and ranibizumab remain confined within the vitreous cavity after intravitreal injection and to determine the pharmacokinetic properties of these agents within the vitreous cavity. Methods: Radiolabeling with I-124 was completed using a modified Iodogen method. After testing for radiochemical purity, three anesthetized...

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Imaging of Retro-Orbital Vasculature and Central Retinal Vasculature with Ultra High Field 7T Magnetic Resonance Imaging Using Dedicated Eye Coil

John B. Christoforidis, P.A. Wassenaar, G.A. Christoforidis, M.V. Knopp, P. Schmalbrock  (Columbus, USA) Advantages:   Noninvasive imaging of retrobulbar vascular structures such as the ophthalmic artery and its branches is challenging because of the fine resolution required. Recent improvements in imaging with ultra high field MRI allows for improved visualization of fine ocular structures. In this study we utilized a dedicated...

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