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Clinical Experience of Ocriplasmin for Vitreomacular Traction and MH

Purpose: To evaluate the anatomical and functional results after ocriplasmin (JETREA, ThromboGenics NV, Iselin, NJ, USA) injection in patients with vitreomacular traction (VMT) with or without macular hole (MH). Methods: Fifteen prospective patients with VMT were treated with a single ocriplasmin injection and followed-up at baseline, 1 week, 1, 3 and 6 months. ETDRS best-corrected visual acuity (BCVA), intraocular pressure and...

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Is PFCL Totally Atoxic and Safe?

Purpose: To describe a very rare complication in vitreo retinal surgery related with a Perfluorocarbon liquid (PFCL). Description: We present 4 cases in which we use PFCL, two of them (Retinal detachment with macula attached and dislocated IOL in vitreous cavity) passed from 20/20 VA to hand movements and a severe central scotoma. All of them we could observe a severe atrophy in macular area with a complete disparition of retinal cell...

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Subretinal Schwann Cell Injections Preserve Plexiform Synapses and Retinal Function in RCS Rats

Isabel Pinilla, MD (Zaragoza, Spain), Nicolás Cuenca, PhD (Alicante, Spain), Yves Sauvé, PhD (Edmonton, Canada), Gema Martínez-Navarrete, (Alicante, Spain), Emilio Abecia Martinez, MD (Zaragoza, Spain), Raymond D. Lund, PhD (Salt Lake City, UT) PURPOSE: To examine the preventive potential of subretinal injections of neurotrophin producing cells (Schwann cells) on retinal circuitry in the RCS (Royal College of Surgeons) rat model of...

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Preservation of Retinal Anatomy and Synaptic Connectivity Following Preventive Subretinal Injections of Human RPE Cells in the Royal College of Surgeons (RCS) Rat

I. Pinilla, Y. Sauvé, N. Cuenca, E. Abecia, R. D. Lund Purpose: To examine the effect of preventive subretinal cell injections in the RCS rat on the outer retina and synaptic connectivity between photoreceptors and their target neurons. Methods: Eight rats received subretinal injections of a human RPE cell line (ARPE19) at age P22; they were sacrificed at P90 (n=4) and P120 (n=4). Controls consisted of 6 unoperated rats sacrificed at the...

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