To observe the foveal avascular zone FAZ) in Zone-I retinopathy of prematurity (ROP), in children born preterm without ROP history and in healty subjects using optical coherence tomography angiography (OCTA) and to analyse the influence of FAZ on visual acuity (VA).


Seventeen Zone-I ROP patients after laserphotocoagulation (group-1; n=19 eyes), 18 children born preterm without ROP history (group-2; n=18 eyes) and 20 healthy subjects (group-3; n=20 eyes) were included. Only one eye of each chidren was analysed in the retrospective study. Visual acuity was detected with Snellen charts. Exclusion criteria were other retinal diseases, trauma, retinal detachment, or congenital macular scar, intraocular inflammation, media opacities preventing detailed imaging, vitreomacular traction syndrome, epiretinal membrane and prior intravitreal injections, or vitreoretinal surgery. Also, eyes with poor fixation due to low visual acuity or poor cooperation and myopia ≥7 diopter. FAZ area was measured using the Optovue RTVue XR AVANTI instrument (Optovue Inc, Fremont, CA) software.


In group-1 (mean age11 years, min-max 9-13, birth weight (BW) 780 ± 470 g, gestational age (GA) 26 ± 3.2 weeks), group-2 (mean age 10.9 years, min-max 9-12, BW 1100±370 g, GA 29±5.6 weeks) and group-3 (mean age 11,4, min-max 9-13 years, BW 3300±400.4 g, GA 38±2 weeks) assessment of 3×3-mm scan area revealed a mean FAZ area of 0.03±0.03 mm2 in group-1, 0.08±0.05 mm2 in group-2 and 0.27±0.12 mm2 in group-3 with significant difference between the groups. FAZ was not detected in three eyes in group-1. VA was 0.4 in group-1, 0.8 in group-2 and 1.0 in group-3. Regarding VA there was a significant difference between group-1 and group-2 and group-3. But no difference was detected between group-2 and group-3.


Preterm birth results in abnormal foveal vascularisation. FAZ area increased with increasing GA. Small GA may result in default of FAZ. Absence or reduced FAZ may depress VA.



Imren AKKOYUN*, Eylem Yaman PINARCI, Deniz ANUK, Gulsah GOKGOZ, Asude AYHAN, Sibel OTO, Gursel YILMAZ
Baskent University, Faculty of Medicine, Department of Ophthalmology
Ankara, Turkey
Email: retina95akk@yahoo.de
Cell Phone: +905376133848
Work Phone: +903122150349