Mehmet Demir_SCIENTIFIC POSTER 2015_1


To investigate the effect of application of a variety of treatment modalities on central macular thickness (CMT), serous macular detachment height (SMD) and best corrected visual acuity (BCVA) in diabetic macular edema (DME) with serous macular detachment.


Eighteen eyes of 15 female and 20 eyes of 13 male Type 2I diabetic patients with DME and SMD applied to Retina Clinic were included in this study. Treatment modalities included single intravitreal bevacizumab 2.5 mg (9 eyes), three doses (one dose per month) bevacizumab 2.5 mg, (15 eyes), 3 three doses (one dose per month) Ranibizumab 0.5 mg (6 eyes), panretinal photocoagulation (3 eyes), intravitreal triamcinolone acetonide 4mg (3 eyes) and grid laser (1 eye). Clinical evaluation included BCVA, OCT imaging with emphasis to CMT, SMD height change, integrity of external limiting membrane and inner segment/outer segment band (IS/OS) at baseline, 1st month, 3rd months and 6th month after treatment. For statistical analysis independent and paired t tests were used.


Proliferative diabetic retinopathy (PDR) was present in 34.2% of the patients. CMT and SMD height decreased significantly when compared to baseline at 1st month, 3rd month and 6th months in both PDR and non-PDR patients. BCVA increased significantly during 1st and 3rd months in PDR group and only at 1st month in non-PDR group. With respect to presence of proliferative diabetic retinopathy (PDR) or non-PDR, there was no correlation between change in SMD height and change in BCVA. Diffuse macular edema with or without cysts was present in half of the patients, cystoid macular edema pattern was present in the other half. Presence of either diffuse or cystoid macular edema OCT pattern had no correlation with BCVA change. Patients with disturbance of ELM and IS/OS band integrity (20 eyes) had significantly lower baseline and follow-up BCVA and lower response to treatment when compared with eyes with continuous ELM and IS/OS band integrity (p<0.05)


Treatment caused a significant decrease in height of SMD and CMT during 6 month follow-up in this series of DME with SMD. Photoreceptor cell layer integrity was found to be an important factor effecting visual acuity gain after treatment.

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